TORCETRAPIB IMPAIRS ENDOTHELIAL FUNCTION IN HYPERTENSION
نویسندگان
چکیده
منابع مشابه
Torcetrapib impairs endothelial function in hypertension.
AIMS A marked increase in HDL notwithstanding, the cholesterol ester transfer protein (CETP) inhibitor torcetrapib was associated with an increase in all-cause mortality in the ILLUMINATE trial. As underlying mechanisms remain elusive, the present study was designed to delineate potential off-target effects of torcetrapib. METHODS AND RESULTS Spontaneously hypertensive rats (SHRs) and Wistar-...
متن کاملAldosterone, sodium, and hypertension: lessons from torcetrapib?
On epidemiological grounds, inhibition of cholesterol ester transport protein (CETP), and, thus, blockade of transfer of cholesterol esters from high-density lipoprotein (“good cholesterol”) to other lipoproteins, represents a promising target in the prevention and treatment of atherosclerosis.1,2 The first large trial to test this hypothesis was the Investigation of Lipid Level Management to U...
متن کاملConjugated linoleic acid impairs endothelial function.
OBJECTIVE To determine the effect of dietary supplementation with conjugated linoleic acid (CLA) on body mass index (BMI), body fat distribution, endothelial function, and markers of cardiovascular risk. METHODS AND RESULTS Forty healthy volunteers with BMI >27 kg/m2 were randomized to receive a CLA isomeric mixture or olive oil in a 12-week double-blind study. Subcutaneous body fat and abdom...
متن کاملActivation of endothelial toll-like receptor 3 impairs endothelial function.
RATIONALE Endothelial dysfunction and atherosclerosis are chronic inflammatory diseases characterized by activation of the innate and acquired immune system. Specialized protein receptors of the innate immune system recognize products of microorganisms and endogenous ligands such as nucleic acids. Toll-like receptor 3 (TLR3), for example, detects long double-stranded RNA and is abundantly expre...
متن کاملEndothelial function in clinical pulmonary hypertension.
The endothelium regulates the concentrations of several types of vasoactive substances that affect pulmonary vascular tone, and endothelia can oppose vasoconstriction in some circumstances by releasing vasodilators. To assess some of these endothelial functions in patients with pulmonary hypertension, we made measurements of selected vasoactive substances before and during attempts at pharmacol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Hypertension
سال: 2011
ISSN: 0263-6352
DOI: 10.1097/00004872-201106001-00153